{"product_id":"proteintech-10037-1-ig","title":"Proteintech, 10037-1-Ig, XIAP Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe XIAP (10037-1-Ig) by Proteintech is a Polyclonal antibody targeting XIAP in WB, IHC, ELISA applications with reactivity to human, mouse, rat samples\n10037-1-Ig targets XIAP in WB, IHC, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: RAW 264.7 cells, Jurkat cells,  HepG2 cells,  COLO 320 cells,  HeLa cells,  C6 cells,  NIH\/3T3 cells,  Raji cells\nPositive IHC detected in: human pancreas cancer tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:2000\nImmunohistochemistry (IHC): IHC : 1:20-1:200\n\u003cb\u003eBackground Information\u003c\/b\u003e\nXIAP, also named as API3, BIRC4 and IAP3, belongs to the IAP family. It has E3 ubiquitin-protein ligase activity. It mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. XIAP is an inhibitor of caspase-3, -7 and -9. It mediates activation of MAP3K7\/TAK1, leading to the activation of NF-kappa-B. XIAP is an apoptotic suppressor. It is ubiquitinated and degraded by the proteasome in apoptotic cells. The MW of XIAP is 45-56 kDa.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nCited Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag0022 Product name: Recombinant human XIAP protein Source: e coli. -derived, Unknow Tag: N\/A Domain: XIAP of BC032729 Sequence: Predict reactive species\nFull Name: X-linked inhibitor of apoptosis\nCalculated Molecular Weight: 60 kDa\nObserved Molecular Weight: 45-57 kDa\nGenBank Accession Number: BC032729\nGene Symbol: XIAP\nGene ID (NCBI): 331\nRRID: AB_2215009\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P98170\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46868842348713,"sku":"10037-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-10037-1-ig","provider":"Iright","version":"1.0","type":"link"}