{"product_id":"proteintech-12722-1-ap","title":"Proteintech, 12722-1-AP, CATSPER1 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe CATSPER1 (12722-1-AP) by Proteintech is a Polyclonal antibody targeting CATSPER1 in WB, ELISA applications with reactivity to human samples\n12722-1-AP targets CATSPER1 in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: human testis tissue\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:1000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCation channel sperm-associated protein 1 (CATSPER1) belongs to a family of four sperm-specific tetrameric voltage-gated cation channels that are highly conserved in humans and mice (PMID: 12402840; 12932298). Definitive evidence that CatSper1 functions as a voltage-gated calcium channel to facilitate hyperactivated sperm motility came from whole-cell patch-clamp measurements of spermatozoa (PMID: 16467839). CATSPER1 channel currents were potentiated in response to intracellular alkalinization, increasing the concentration of intraflagellar calcium and thereby inducing hyperactivity.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag3417 Product name: Recombinant human CATSPER1 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-302 aa of BC032950 Sequence: MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHPPEFQDFHDQALSSHVHQSHHHSEARNHVRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRDGRRHHDGSQYSGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYLPHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKSPHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYHQH Predict reactive species\nFull Name: cation channel, sperm associated 1\nCalculated Molecular Weight: 780 aa, 90 kDa\nObserved Molecular Weight: 90 kDa\nGenBank Accession Number: BC032950\nGene Symbol: CATSPER1\nGene ID (NCBI): 117144\nRRID: AB_3669148\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q8NEC5\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46885841535145,"sku":"12722-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-12722-1-ap","provider":"Iright","version":"1.0","type":"link"}