{"product_id":"proteintech-21437-1-ap","title":"Proteintech, 21437-1-AP, FBXL21 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe FBXL21 (21437-1-AP) by Proteintech is a Polyclonal antibody targeting FBXL21 in IHC, IF\/ICC, ELISA applications with reactivity to human, mouse samples\n21437-1-AP targets FBXL21 in IHC, IF\/ICC, ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive IHC detected in: mouse heart tissue, mouse lung tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\nPositive IF\/ICC detected in: C2C12 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nImmunohistochemistry (IHC): IHC : 1:50-1:500\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:50-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nFBXL21 (F-box and leucine-rich repeat protein 21) is a member of the F-box protein family, which plays a crucial role in regulating protein degradation through the ubiquitin-proteasome system. FBXL21 has been identified as a regulator in skeletal muscle. It mediates the rhythmic degradation of sarcomere proteins such as TCAP (titin cap) and MYOZ1 (Myozenin1) in conjunction with GSK-3β (PMID: 36574402).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag16049 Product name: Recombinant human FBXL21 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 221-434 aa of BC106753 Sequence: GILCVADRCQGLRELALNYYILTDELFLALSSETHVNLEHLRIDVVSENPGQIKFHAVKKHSWDALIKHSPRVNVVMHFFLYEEEFETFFKEETPVTHLYFGRSVSKVVLGRVGLNCPRLIELVVCANDLQPLDNELICIAEHCTNLTALGLSKCEVSCSAFIRFVRLCERRLTQLSVMEEVLIPDEDYSLDEIHTEVSKYLGRVWFPDVMPLW Predict reactive species\nFull Name: F-box and leucine-rich repeat protein 21\nCalculated Molecular Weight: 434 aa, 49 kDa\nGenBank Accession Number: BC106753\nGene Symbol: FBXL21\nGene ID (NCBI): 26223\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q3KPF8\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887636172969,"sku":"21437-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-21437-1-ap","provider":"Iright","version":"1.0","type":"link"}