{"product_id":"proteintech-28331-1-ap","title":"Proteintech, 28331-1-AP, IL-4RA\/CD124 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe IL-4RA\/CD124 (28331-1-AP) by Proteintech is a Polyclonal antibody targeting IL-4RA\/CD124 in WB, IHC, ELISA applications with reactivity to human samples\n28331-1-AP targets IL-4RA\/CD124 in WB, IHC, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Daudi cells\nPositive IHC detected in: human tonsillitis tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:1000\nImmunohistochemistry (IHC): IHC : 1:300-1:1200\n\u003cb\u003eBackground Information\u003c\/b\u003e\nIL-4 receptor alpha chain (IL-4RA), also known as CD124, is a transmembrane glycoprotein expressed on a wide variety of hematopoietic and non-hematopoietic cells. It is a receptor for both IL-4 and IL-13. IL-4RA can complex with the common gamma chain (IL-2R gamma or CD132) and utilizes JAK1 and JAK2 for signal transduction, while complexes of IL-4RA with IL-13RA1 subunit mediate signals via JAK2 and Tyk2. The IL-4 response is involved in promoting Th2 differentiation. The IL-4\/IL-13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nCited Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag28766 Product name: Recombinant human IL-4R protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 257-465 aa of NM_000418 Sequence: MKIKKEWWDQIPNPARSRLVAIIIQDAQGSQWEKRSRGQEPAKCPHWKNCLTKLLPCFLEHNMKRDEDPHKAAKEMPFQGSGKSAWCPVEISKTVLWPESISVVRCVELFEAPVECEEEEEVEEEKGSFCASPESSRDDFQEGREGIVARLTESLFLDLLGEENGGFCQQDMGESCLLPPSGSTSAHMPWDEFPSAGPKEAPPWGKEQPL Predict reactive species\nFull Name: interleukin 4 receptor\nCalculated Molecular Weight: 90 kDa\nObserved Molecular Weight: 120-140 kDa\nGenBank Accession Number: NM_000418\nGene Symbol: IL-4R\nGene ID (NCBI): 3566\nRRID: AB_2881115\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: P24394\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46869001175209,"sku":"28331-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-28331-1-ap","provider":"Iright","version":"1.0","type":"link"}