{"product_id":"proteintech-28965-1-ap","title":"Proteintech, 28965-1-AP, Phospho-STK11\/LKB1 (Thr189) Polyclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-STK11\/LKB1 (Thr189) (28965-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-STK11\/LKB1 (Thr189) in WB, ELISA applications with reactivity to Human, mouse samples\n28965-1-AP targets Phospho-STK11\/LKB1 (Thr189) in WB, ELISA applications and shows reactivity with Human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Calyculin A treated PC-3 cells, UV treated NIH\/3T3 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nLiver kinase 1 (LKB1 also known as STK11) is a tumor suppressor gene that is inactivated by bi-allelic mutation in non-small cell lung cancer (NSCLC), malignant melanoma and cervical cancer. LKB1 protein has a central kinase domain, two N-terminal nuclear leading sequences, and a C-terminal regulatory motif. The protein also contains a CAAX motif at C-terminal end and can be farnesylated. The formation of an LKB1\/Strad\/MO25 complex is essential for LKB1's kinase activity, and there are at least 13 known substrates of LKB1, which includes AMPKs, BRSKs, and MARKs. LKB1 is the major kinase that phosphorylates the AMPK activation loop in conditions of energy stress. (PMID: 25679014, PMID: 19629071)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human, mouse\nCited Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: serine\/threonine kinase 11\nCalculated Molecular Weight: 49 kDa\nObserved Molecular Weight: 50-55 kDa\nGenBank Accession Number: BC007981\nGene Symbol: LKB1\nGene ID (NCBI): 6794\nRRID: AB_2918225\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q15831\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46869729935529,"sku":"28965-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-28965-1-ap","provider":"Iright","version":"1.0","type":"link"}