{"product_id":"proteintech-28983-1-ap","title":"Proteintech, 28983-1-AP, Phospho-RPS6KA1 (Ser380) Polyclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-RPS6KA1 (Ser380) (28983-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-RPS6KA1 (Ser380) in WB, IF\/ICC, ELISA applications with reactivity to human, mouse samples\n28983-1-AP targets Phospho-RPS6KA1 (Ser380) in WB, IF\/ICC, ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Calyculin A treated HeLa cells\nPositive IF\/ICC detected in: λ phosphatase treated NIH\/3T3 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:2000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:50-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nThe 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed serine\/threonine kinases and play an important role in the MAPK signaling cascade and act downstream of ERK1\/2 signaling. It can mediate mitogenic and stress-induced activation of the transcription factors CREB1, ETV1\/ER81 and NR4A1\/NUR77. RSK1 (RPS6KA1) is also designated as p90RSK associated with cellular proliferation, survival and differentiation. It has been reported that the phosphorylation of RPS6KA1 at Ser380 is involved in autophosphorylation by activation of the C-terminal kinase domain. (PMID: 16458888, 30813401, 17259979, 10679322)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nCited Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: ribosomal protein S6 kinase, 90kDa, polypeptide 1\nCalculated Molecular Weight: 735 aa, 83 kDa\nObserved Molecular Weight: 83-90 kDa\nGenBank Accession Number: BC014966\nGene Symbol: RPS6KA1\nGene ID (NCBI): 6195\nRRID: AB_2881237\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q15418\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46869571895465,"sku":"28983-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-28983-1-ap","provider":"Iright","version":"1.0","type":"link"}