{"product_id":"proteintech-29503-1-ap","title":"Proteintech, 29503-1-AP, Phospho-P62\/SQSTM1 (Ser349) Polyclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-P62\/SQSTM1 (Ser349) (29503-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-P62\/SQSTM1 (Ser349) in WB, ELISA applications with reactivity to human, mouse samples\n29503-1-AP targets Phospho-P62\/SQSTM1 (Ser349) in WB, IF, ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: MG132 treated HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:16000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nSequestosome 1 (SQSTM1\/p62) is a multifunctional adaptor protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis. It functions as a bridge between polyubiquitinated cargo and autophagosomes (PMID:16286508). SQSTM1 is at the cross-roads of several signaling pathways including Keap1-Nrf2 pathway , NFκB pathway , NFE2L2\/NRF2 pathway , mTOR pathway and Wnt pathway. Phosphorylation and\/or de-phosphorylation of p62-Ser349 may participate in the regulation of both selective autophagy and oxidative stress response (PMID: 33397898).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nCited Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: sequestosome 1\nCalculated Molecular Weight: 48 kDa\nObserved Molecular Weight: 62 kDa\nGenBank Accession Number: BC017222\nGene Symbol: P62\/SQSTM1\nGene ID (NCBI): 8878\nRRID: AB_2923592\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q13501\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46868935737513,"sku":"29503-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-29503-1-ap","provider":"Iright","version":"1.0","type":"link"}