{"product_id":"proteintech-29568-1-ap","title":"Proteintech, 29568-1-AP, Phospho-PLCG2 (Tyr1217) Polyclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-PLCG2 (Tyr1217) (29568-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-PLCG2 (Tyr1217) in WB, ELISA applications with reactivity to Human samples\n29568-1-AP targets Phospho-PLCG2 (Tyr1217) in WB, ELISA applications and shows reactivity with Human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: pervanadate treated Raji cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:2000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nPhospholipase C gamma 2 (PLCG2) belongs to the family of phospholipase C-gamma, which is the downstream molecule of the CSF1R. Previous studies have demonstrated that PLCG2 was required for CSF1-induced differentiation of monocytes, microglia, immune, inflammatory responses. PLCG2 phosphorylation leads to an increase in production of the cellular signaling molecules, diacylglycerol (DAG), and inositol 1,4,5 trisphosphate (IP3), which further promotes a wide range of downstream signals, including the phosphorylation of protein kinase C (PKC) family members, such as PKC epsilon (PKCε). (PMID: 32522286)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: phospholipase C, gamma 2 (phosphatidylinositol-specific)\nCalculated Molecular Weight: 148 kDa\nObserved Molecular Weight: 148-150 kDa\nGenBank Accession Number: BC007565\nGene Symbol: PLCG2\nGene ID (NCBI): 5336\nRRID: AB_3669689\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: P16885\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887760953513,"sku":"29568-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-29568-1-ap","provider":"Iright","version":"1.0","type":"link"}