{"product_id":"proteintech-31488-1-ap","title":"Proteintech, 31488-1-AP, TMCO3 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe TMCO3 (31488-1-AP) by Proteintech is a Polyclonal antibody targeting TMCO3 in IP, ELISA applications with reactivity to human samples\n31488-1-AP targets TMCO3 in IP, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive IP detected in: HepG2 cells, HuH-7 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nImmunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate\n\u003cb\u003eBackground Information\u003c\/b\u003e\nTMCO3, also known as transmembrane and coiled-coil domains 3 or C13orf11, is a protein-coding gene with functional annotation of probable Na+\/H+ antiporter.  It belongs to the monovalent cation:proton antiporter-2 (CPA2) family according to the Transporter Classification Database (TCDB) (PMID: 33170213). Most CPA2 family members have similar functions and are involved in ion transport (K+, Na+, and H+) in bacteria, archaea, insects, and plants. Upregulated TMCO3 could act as an oncogenic mediator and promote sorafenib resistance in HCC, providing a potential therapeutic target for HCC treatment (PMID: 36304514).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag35012 Product name: Recombinant human TMCO3 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 23-285 aa of BC068515 Sequence: VEHEEVAQRVIKLHRGRGVAAMQSRQWVRDSCRKLSGLLRQKNAVLNKLKTAIGAVEKDVGLSDEEKLFQVHTFEIFQKELNESENSVFQAVYGLQRALQGDYKDVVNMKESSRQRLEALREAAIKEETEYMELLAAEKHQVEALKNMQHQNQSLSMLDEILEDVRKAADRLEEEIEEHAFDDNKSVKGVNFEAVLRVEEEEANSKQNITKREVEDDLGLSMLIDSQNNQYILTKPRDSTIPRADHHFIKDIVTIGMLSLPCG Predict reactive species\nFull Name: transmembrane and coiled-coil domains 3\nCalculated Molecular Weight: 75 kDa\nObserved Molecular Weight: 70 kDa\nGenBank Accession Number: BC068515\nGene Symbol: TMCO3\nGene ID (NCBI): 55002\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity Purification\nUNIPROT ID: Q6UWJ1\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887829602473,"sku":"31488-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-31488-1-ap","provider":"Iright","version":"1.0","type":"link"}