{"product_id":"proteintech-32938-1-ap","title":"Proteintech, 32938-1-AP, TTBK1 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe TTBK1 (32938-1-AP) by Proteintech is a Polyclonal antibody targeting TTBK1 in WB, ELISA applications with reactivity to human, mouse, rat samples\n32938-1-AP targets TTBK1 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: SH-SY5Y cells, fetal human brain tissue,  mouse brain tissue,  rat brain tissue\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:6000-1:12000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nTTBK1 (Tau Tubulin kinase 1), also known as BDTK (brain-derived Tau kinase), is a 1,321 amino acid protein that contains one protein kinase domain and belongs to the serine\/threonine protein kinase family. Localized to the cytoplasm and expressed at high levels in brain and at lower levels in testis and spinal cord, TTBK1 functions as a serine\/threonine kinase that can phosphorylate Tau (a protein involved in Tubulin polymerization) on threonine, tyrosine and serine residues. Specifically, TTBK1 uses divalent cations, such as magnesium and manganese, to catalyze the ATP-dependent transfer of a phosphate group onto Tau, creating a phosphoprotein and ADP. Phosphorylation of Tau causes its aggregation and subsequent loss of function, suggesting an important role for TTBK1 in the control of Tubulin dynamics. Two isoforms of TTBK1 are expressed due to alternative splicing events. The molecular weight observed is consistent with what has been described in PMID:16923168.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag36655 Product name: Recombinant human TTBK1 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1060-1321 aa of BC036764 Sequence: LSEEDTGSEPSGSLSAKERWSKRARPQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPAAALPRKSGRAAATRSRIPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSRLQLQTPPGSATAADLRPKQPPGRGLGPGRAQAGARPPAPRSPRLPASTSAARNASASPRSQSLSRRESPSPSHQARPGVPPPRGVPPARAQPDGTPSPGGSKKGPRGKLQAQRATTKGRAGGAEGRAGAR Predict reactive species\nFull Name: tau tubulin kinase 1\nCalculated Molecular Weight: 142\/70 kDa\nObserved Molecular Weight: 200 kDa\nGenBank Accession Number: BC036764\nGene Symbol: TTBK1\nGene ID (NCBI): 84630\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity Purification\nUNIPROT ID: Q5TCY1\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887909785769,"sku":"32938-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-32938-1-ap","provider":"Iright","version":"1.0","type":"link"}