{"product_id":"proteintech-55145-1-ap","title":"Proteintech, 55145-1-AP, CAPZA1 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe CAPZA1 (55145-1-AP) by Proteintech is a Polyclonal antibody targeting CAPZA1 in WB, IHC, ELISA applications with reactivity to human, mouse samples\n55145-1-AP targets CAPZA1 in WB, IHC, ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: human heart tissue,  mouse brain tissue,  mouse heart tissue\nPositive IHC detected in: human colon cancer tissue,  human stomach cancer tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:200-1:1000\nImmunohistochemistry (IHC): IHC : 1:20-1:200\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCAPZA1 belongs to the F-actin-capping protein alpha subunit family.  F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. The potential for CAPZ is a therapeutic target in the management of heart failure. Future research is required to determine the mechanisms by which changes in CAPZ impact myocardial function and intracellular signalling, and to develop feasible strategies that can manipulate CAPZ in the intact heart. (PMID: 15614336 ) This antibody is specific to CAPZA1.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: capping protein (actin filament) muscle Z-line, alpha 1\nCalculated Molecular Weight: 33 kDa\nObserved Molecular Weight: 34-40 kDa\nGenBank Accession Number: NM_006135\nGene Symbol: CAPZA1\nGene ID (NCBI): 829\nRRID: AB_11182940\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: P52907\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46885807194281,"sku":"55145-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-55145-1-ap","provider":"Iright","version":"1.0","type":"link"}