{"product_id":"proteintech-65146-1-ig","title":"Proteintech, 65146-1-Ig, Anti-Human CD8 (SK1)","description":"Size: 100ug \/ 500ug\nThe CD8 (65146-1-Ig) by Proteintech is a Monoclonal antibody targeting CD8 in FC applications with reactivity to human samples\n65146-1-Ig targets CD8 in FC applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive FC detected in: human PBMCs\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nFlow Cytometry (FC): FC : 0.2 ug per 10^6 cells in 100 μl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells , on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-\/CD8+ T cells (PMID: 1968084).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Mouse \/ IgG1, kappa\nClass: Monoclonal\nType: Antibody\nImmunogen: Human peripheral blood T lymphocytes Predict reactive species\nFull Name: CD8a molecule\nCalculated Molecular Weight: 235 aa, 26 kDa\nGenBank Accession Number: BC025715\nGene Symbol: CD8A\nGene ID (NCBI): 925\nENSEMBL Gene ID: ENSG00000153563\nRRID: AB_2918431\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Affinity purification\nUNIPROT ID: P01732\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2-8°C. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888094335145,"sku":"65146-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-65146-1-ig","provider":"Iright","version":"1.0","type":"link"}