{"product_id":"proteintech-65168-1-ig","title":"Proteintech, 65168-1-Ig, Anti-Human PD-1\/CD279 (EH12.2H7)","description":"Size: 100ug \/ 500ug\nThe PD-1\/CD279 (65168-1-Ig) by Proteintech is a Monoclonal antibody targeting PD-1\/CD279 in FC applications with reactivity to human, non-human primates samples\n65168-1-Ig targets PD-1\/CD279 in FC applications and shows reactivity with human, non-human primates samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive FC detected in: PHA treated human PBMCs\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nFlow Cytometry (FC): FC : 0.2 ug per 10^6 cells in 100 μl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nProgrammed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28\/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, non-human primates\nHost \/ Isotype: Mouse \/ IgG1, kappa\nClass: Monoclonal\nType: Antibody\nImmunogen: Recombinant human CD279 protein Predict reactive species\nFull Name: programmed cell death 1\nCalculated Molecular Weight: 288 aa, 32 kDa\nGenBank Accession Number: BC074740\nGene Symbol: PD-1\nGene ID (NCBI): 5133\nRRID: AB_2918445\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Purified by protein-A affinity chromatography\nUNIPROT ID: Q15116\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2-8°C. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888095809705,"sku":"65168-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-65168-1-ig","provider":"Iright","version":"1.0","type":"link"}