{"product_id":"proteintech-65241-1-ig","title":"Proteintech, 65241-1-Ig, Anti-Mouse E-cadherin (DECMA-1)","description":"Size: 100ug \/ 500ug\nThe E-cadherin (65241-1-Ig) by Proteintech is a Monoclonal antibody targeting E-cadherin in IF-P, FC applications with reactivity to human, mouse, canine samples\n65241-1-Ig targets E-cadherin in IF-P, FC applications and shows reactivity with human, mouse, canine samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive IF-P detected in: mouse colon tissue\nPositive FC detected in: MDCK cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nImmunofluorescence (IF)-P: IF-P : 1:625-1:2500\nFlow Cytometry (FC): FC : 0.2 ug per 10^6 cells in 100 μl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CDH1 (cadherin 1) or CAM 120\/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. It has been regarded as a marker for spermatogonial stem cells in mice(PMID:23509752). E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, canine\nHost \/ Isotype: Rat \/ IgG1, kappa\nClass: Monoclonal\nType: Antibody\nImmunogen: Mouse embryonal carcinoma cell line PCC4 Aza RI Predict reactive species\nFull Name: cadherin 1\nGenBank Accession Number: BC098501\nGene Symbol: E-cadherin\nGene ID (NCBI): 12550\nRRID: AB_2935150\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Affinity purification\nUNIPROT ID: P09803\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2-8°C. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888097349801,"sku":"65241-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-65241-1-ig","provider":"Iright","version":"1.0","type":"link"}