{"product_id":"proteintech-65577-1-mr","title":"Proteintech, 65577-1-MR, Anti-Rat CD8a (OX-8) Mouse IgG2a Recombinant Antibody","description":"Size: 100ug\nThe CD8a (65577-1-MR) by Proteintech is a Recombinant antibody targeting CD8a in FC applications with reactivity to rat samples\n65577-1-MR targets CD8a in FC applications and shows reactivity with rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive FC detected in: rat splenocytes\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nFlow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells , on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-\/CD8+ T cells (PMID: 1968084).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: rat\nHost \/ Isotype: Mouse \/ IgG2a\nClass: Recombinant\nType: Antibody\nImmunogen: High-molecular-weight rat thymocyte glycoproteins Predict reactive species\nFull Name: CD8a molecule\nGenBank Accession Number: BC088126\nGene Symbol: Cd8a\nGene ID (NCBI): 24930\nRRID: AB_3670330\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P07725\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2-8°C. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888586838185,"sku":"65577-1-MR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-65577-1-mr","provider":"Iright","version":"1.0","type":"link"}