{"product_id":"proteintech-65583-1-mr","title":"Proteintech, 65583-1-MR, Anti-Human CD49b (AK7) Mouse IgG2a Recombinant Antibody","description":"Size: 100ug\nThe CD49b (65583-1-MR) by Proteintech is a Recombinant antibody targeting CD49b in FC applications with reactivity to human samples\n65583-1-MR targets CD49b in FC applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive FC detected in: human peripheral blood platelets\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nFlow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCD49b, also known as alpha2 integrin, is a type I transmembrane glycoprotein which forms an adhesion molecule VLA-2 with beta1 integrin. CD49b is a receptor for many (extracellular) matrix and non-matrix molecules (PMID: 23847623). CD49b is expressed on numerous cell types including platelets, activated T cells, B cells, and monocytes. CD49b activation skews NK cell effector function to a phenotype that exhibits elevated IFN-γ production with a concomitant inhibition of motility and cytolytic function (PMID: 32971468, 32762681). The Anti-Human CD49b antibody, clone AK7, is derived from Human platelets.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Mouse \/ IgG2a\nClass: Recombinant\nType: Antibody\nImmunogen: Human platelets Predict reactive species\nFull Name: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)\nCalculated Molecular Weight: 126 kDa\nGenBank Accession Number: NM_002203\nGene Symbol: Integrin alpha 2\nGene ID (NCBI): 3673\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P17301\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2-8°C. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888544338089,"sku":"65583-1-MR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-65583-1-mr","provider":"Iright","version":"1.0","type":"link"}