{"product_id":"proteintech-65663-1-tr","title":"Proteintech, 65663-1-TR, Anti-Mouse MHC Class II (I-A\/I-E) (M5\/114.15.2) Rat Recombinant Antibody","description":"Size: 100ug\nThe MHC Class II (I-A\/I-E) (65663-1-TR) by Proteintech is a Recombinant antibody targeting MHC Class II (I-A\/I-E) in FC applications with reactivity to mouse samples\n65663-1-TR targets MHC Class II (I-A\/I-E) in FC applications and shows reactivity with mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive FC detected in: mouse splenocytes\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nFlow Cytometry (FC): FC : 0.5 ug per 10^6 cells in 100 μl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nMajor histocompatibility complex (MHC) class II molecules are heterodimeric transmembrane glycoproteins that are expressed on the surface of antigen-presenting cells such as dendritic cells, macrophages, and B cells. The M5\/114.15.2 antibody detects polymorphic determinants present on B cells, monocytes, macrophages, dendritic cells, and activated T lymphocytes from mice carrying the H-2b, H-2d, H-2q, H-2p, H-2r and H-2u haplotypes but not from mice carrying the H-2s or H-2f haplotypes (PMID: 6170707). This antibody recognizes both I-A and I-E subregion-encoded Ia glycoproteins (I-Ab, I-Ad, I-Aq, I-Ed, I-Ek, not I-Af, I-Ak, or I-As). M5\/114 antibody is reported to inhibit I-A subregion-restricted T cell responses of the H-2b, H-2d, H-2q, H-2u but not the H-2f, H-2k, H-2s haplotypes (PMID: 6173436).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: mouse\nHost \/ Isotype: Rat \/ IgG2a\nClass: Recombinant\nType: Antibody\nImmunogen: N\/A Predict reactive species\nFull Name: histocompatibility 2, class II antigen A, alpha\nGenBank Accession Number: BC031711\nGene Symbol: MHC Class II\nGene ID (NCBI): 14960\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P14434\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2-8°C. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888578613417,"sku":"65663-1-TR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-65663-1-tr","provider":"Iright","version":"1.0","type":"link"}