{"product_id":"proteintech-65684-2-mr","title":"Proteintech, 65684-2-MR, Anti-Mouse PD-1\/CD279 (RMP1-14) Mouse IgG2a Recombinant Antibody","description":"Size: 100ug\nThe PD-1\/CD279 (65684-2-MR) by Proteintech is a Recombinant antibody targeting PD-1\/CD279 in FC, Blocking, Functional Assay applications with reactivity to mouse samples\n65684-2-MR targets PD-1\/CD279 in FC, Blocking, Functional Assay applications and shows reactivity with mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive Functional Assay detected in: Recombinant protein\nPositive FC detected in: anti-CD3\/CD28 treated mouse splenocytes\nPositive Blocking detected in: Recombinant protein\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nFUNCTIONAL ASSAY: FUNCTIONAL ASSAY :\nFlow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension\nBLOCKING: BLOCKING :\n\u003cb\u003eBackground Information\u003c\/b\u003e\nProgrammed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28\/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436). RMP1-14 is a monoclonal antibody that targets the murine PD-1 protein and can be used in mouse models to block the reaction between PD-1 and PD-L1\/PD-L2 (PMID: 14764726; 31832706).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: mouse\nHost \/ Isotype: Mouse \/ IgG2a\nClass: Recombinant\nType: Antibody\nImmunogen: Mouse PD-1 transfected BHK cells Predict reactive species\nFull Name: programmed cell death 1\nGenBank Accession Number: BC119179\nGene Symbol: PD-1\nGene ID (NCBI): 18566\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2-8°C. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888704442537,"sku":"65684-2-MR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-65684-2-mr","provider":"Iright","version":"1.0","type":"link"}