{"product_id":"proteintech-66867-2-ig","title":"Proteintech, 66867-2-Ig, RICTOR Monoclonal antibody","description":"Size: 20ul \/ 150ul\nThe RICTOR (66867-2-Ig) by Proteintech is a Monoclonal antibody targeting RICTOR in WB, IF\/ICC, ELISA applications with reactivity to human, mouse, rat samples\n66867-2-Ig targets RICTOR in WB, IF\/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: NCI-H1299 cells, HeLa cells,  HEK-293 cells,  HepG2 cells,  Jurkat cells,  HSC-T6 cells,  PC-12 cells,  NIH\/3T3 cells\nPositive IF\/ICC detected in: NIH\/3T3 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:6000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:850-1:3400\n\u003cb\u003eBackground Information\u003c\/b\u003e\nRICTOR, is a key component of the mTOR complex 2 (mTORC2) and is required for phosphorylation of Akt at serine 473. RICTOR is the upstream kinase of several AGC kinase family members including AKT, SGK, S6K mutants and several PKC isoforms. Activation of RICTOR-mTORC2 modifies actin organization and promotes cell proliferation and survival. Rictor is overexpressed in several cancers leading to hyperactive mTORC2 and has been shown to play a causal role in glioma formation. Rictor expression has been demonstrated to be regulated transcriptionally and via protein degradation.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nCited Reactivity: human\nHost \/ Isotype: Mouse \/ IgG1\nClass: Monoclonal\nType: Antibody\nImmunogen: CatNo: Ag28487 Product name: Recombinant human RICTOR protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-183 aa of BC029608 Sequence: MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQERDRM Predict reactive species\nFull Name: rapamycin-insensitive companion of mTOR\nCalculated Molecular Weight: 192 kDa\nObserved Molecular Weight: 192 kDa\nGenBank Accession Number: BC029608\nGene Symbol: RICTOR\nGene ID (NCBI): 253260\nRRID: AB_2882204\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein G purification\nUNIPROT ID: Q6R327\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888023097513,"sku":"66867-2-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-66867-2-ig","provider":"Iright","version":"1.0","type":"link"}