{"product_id":"proteintech-67565-1-ig","title":"Proteintech, 67565-1-Ig, PDE6D Monoclonal antibody","description":"Size: 20ul \/ 150ul\nThe PDE6D (67565-1-Ig) by Proteintech is a Monoclonal antibody targeting PDE6D in WB, IHC, ELISA applications with reactivity to human, mouse, rat, pig samples\n67565-1-Ig targets PDE6D in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat, pig samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Jurkat cells, HeLa cells,  HepG2 cells,  human placenta tissue,  rat retina tissue,  mouse brain tissue,  JAR cells,  Pig brain tissue,  Rat brain tissue\nPositive IHC detected in: mouse brain tissue, rat brain tissue,  rat stomach tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\nImmunohistochemistry (IHC): IHC : 1:250-1:1000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nPDE6D, also known as PDED, belongs to the PDE6D\/unc-119 family. PDE6D is a ubiquitously expressed prenyl-binding protein. By binding to prenyl moieties, PDE6D mediates the shuttling of prenylated proteins between membranes. Thereby, it regulates the membrane association of Ras and Rap GTPases (PMID: 36672247). In addition, research has shown that PDE6D is overexpressed in liver cancer and correlated with tumor stages, grading, and ERK activation (PMID: 30901922). The calculated molecular weight of PDE6D is 17 kDa.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat, pig\nCited Reactivity: human, mouse\nHost \/ Isotype: Mouse \/ IgG1\nClass: Monoclonal\nType: Antibody\nImmunogen: CatNo: Ag29563 Product name: Recombinant human PDE6D protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-150 aa of NM_002601 Sequence: MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV Predict reactive species\nFull Name: phosphodiesterase 6D, cGMP-specific, rod, delta\nCalculated Molecular Weight: 17 KDa\nObserved Molecular Weight: 15-17 kDa\nGenBank Accession Number: NM_002601\nGene Symbol: PDE6D\nGene ID (NCBI): 5147\nRRID: AB_2882779\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein G purification\nUNIPROT ID: O43924\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888070414505,"sku":"67565-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-67565-1-ig","provider":"Iright","version":"1.0","type":"link"}