{"product_id":"proteintech-68076-1-ig","title":"Proteintech, 68076-1-Ig, BAG3 Monoclonal antibody","description":"Size: 20ul \/ 150ul\nThe BAG3 (68076-1-Ig) by Proteintech is a Monoclonal antibody targeting BAG3 in WB, IF\/ICC, ELISA applications with reactivity to human, mouse, rat, pig, rabbit samples\n68076-1-Ig targets BAG3 in WB, IHC, IF\/ICC, ELISA applications and shows reactivity with human, mouse, rat, pig, rabbit samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: NIH\/3T3 cells, LNCaP cells,  rabbit heart tissue,  HeLa cells,  pig heart,  rat heart\nPositive IF\/ICC detected in: HepG2 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:500-1:2000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nBAG3 (Bcl2-associated athanogene 3) belongs to the BAG protein family, the co-chaperone that  binds to Hsc70\/Hsp70 through the BAG domain and modulates their activity in polypeptide folding. BAG3 contains also a WW domain and a proline-rich (PXXP) repeat, that mediate binding to partners different from Hsp70. Through interacting with different molecular partner, BAG3 influences several cell processes, such as apoptosis, autophagy and cell motility. BAG3 protein has been reported to sustain cell survival, resistance to therapy, and\/or motility and metastatization in several tumor types, thus being identified as a potential target for anticancer therapies. In addition, defects in BAG3 are the cause of some myopathy.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat, pig, rabbit\nCited Reactivity: human, rat\nHost \/ Isotype: Mouse \/ IgG1\nClass: Monoclonal\nType: Antibody\nImmunogen: CatNo: Ag17608 Product name: Recombinant human BAG3 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 275-575 aa of BC006418 Sequence: SREGSPARSSTPLHSPSPIRVHTVVDRPQQPMTHRETAPVSQPENKPESKPGPVGPELPPGHIPIQVIRKEVDSKPVSQKPPPPSEKVEVKVPPAPVPCPPPSPGPSAVPSSPKSVATEERAAPSTAPAEATPPKPGEAEAPPKHPGVLKVEAILEKVQGLEQAVDNFEGKKTDKKYLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKAIDVPGQVQVYELQPSNLEADQPLQAIMEMGAVAADKGKKNAGNAEDPHTETQQPEATAAATSNPSSMTDTPGNPAAP Predict reactive species\nFull Name: BCL2-associated athanogene 3\nCalculated Molecular Weight: 61 kDa\nObserved Molecular Weight: 74 kDa\nGenBank Accession Number: BC006418\nGene Symbol: BAG3\nGene ID (NCBI): 9531\nRRID: AB_2918814\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein G purification\nUNIPROT ID: O95817\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888025391273,"sku":"68076-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-68076-1-ig","provider":"Iright","version":"1.0","type":"link"}