{"product_id":"proteintech-68092-1-ig","title":"Proteintech, 68092-1-Ig, MIST1 Monoclonal antibody","description":"Size: 20ul \/ 150ul\nThe MIST1 (68092-1-Ig) by Proteintech is a Monoclonal antibody targeting MIST1 in WB, ELISA applications with reactivity to Human, Pig, Rat , Mouse samples\n68092-1-Ig targets MIST1 in WB, ELISA applications and shows reactivity with Human, Pig, Rat , Mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: BxPC-3 cells, SW 1990 cells，Pig pancreas tissue,  Rat pancreas tissue\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nMuscle intestine stomach expression 1 (MIST1), also named bHLHa15, is a secretory cell transcription factor that belongs to the basic helix-loop-helix superfamily. MIST1 is mainly expressed in serous secreted cells and essential for the development and maturation of secretory cells. Secretory cells lacking MIST1 exhibit structural and functional defects, including alterations in cytoskeletal organization and cell polarity and improper cell-cell junction. In healthy pancreata, MIST1 facilitates cell-to-cell communication, promotes acinar cell polarity, controls Ca2+ flux, promotes unfolded protein response (UPR) homeostasis, aids in vesicle assembly, and is required for regulated exocytosis. MIST1 was downregulated in pancreatic cancer tissues compared with normal or adjacent pancreatic tissues and lower MIST1 expression in pancreatic cancer cell lines than normal acinar cells (BxPC-3, PANC-1, SW 1990) (PMID:29859299). MIST1 is downregulated in the development of gastric cancer and in gastric cancer cells compared with SW620 cells (PMID:34149921).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human, Pig, Rat , Mouse\nHost \/ Isotype: Mouse \/ IgG2a\nClass: Monoclonal\nType: Antibody\nImmunogen: CatNo: Ag18509 Product name: Recombinant human BHLHA15 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-189 aa of BC113394 Sequence: MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRSRPARAAARAPGEGRRRRPGPSGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEAQPQGHLQRYSTQIHSFREGT Predict reactive species\nFull Name: basic helix-loop-helix family, member a15\nCalculated Molecular Weight: 189 aa, 21 kDa\nObserved Molecular Weight: 27 kDa\nGenBank Accession Number: BC113394\nGene Symbol: MIST1\nGene ID (NCBI): 168620\nRRID: AB_2918829\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q7RTS1\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888293269673,"sku":"68092-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-68092-1-ig","provider":"Iright","version":"1.0","type":"link"}