{"product_id":"proteintech-68853-7-ig","title":"Proteintech, 68853-7-Ig, CLCC1 Monoclonal antibody","description":"Size: 20ul \/ 150ul\nThe CLCC1 (68853-7-Ig) by Proteintech is a Monoclonal antibody targeting CLCC1 in WB, ELISA applications with reactivity to human samples\n68853-7-Ig targets CLCC1 in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: COLO 320 cells, HepG2 cells,  hTERT-RPE1 cells,  HeLa cells,  K-562 cells,  FaDu cells,  SiHa cells,  SCaBER cells,  MG-63 cells,  MDA-MB-468 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCLCC1, also known as MCLC, is a transmembrane protein that localizes to intracellular compartments, including endoplasmic reticulum (ER), and it functions as a chloride channel (PMID: 11279057). It has been shown that loss of CLCC1 results in ER Stress, misfolded protein accumulation, and neurodegeneration (PMID: 25698737). CLCC1 forms homomultimer in the ER membrane and is a pore-forming component of an anion channel. Studies found that disruption of ER ion homeostasis maintained by CLCC1 is one of the causes of neurodegenerative diseases, such as ALS (amyotrophic lateral sclerosis) (PMID: 37142673).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Mouse \/ IgG1\nClass: Monoclonal\nType: Antibody\nImmunogen: CatNo: Ag24682 Product name: Recombinant human CLCC1 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 315-501 aa of BC002939 Sequence: GPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQSAKPVSGQDTSGNTEGSPAAEKAQLKSEAAGSPDQGSTYSPARGVAGPRGQDPVSSPCG Predict reactive species\nFull Name: chloride channel CLIC-like 1\nCalculated Molecular Weight: 551 aa, 62 kDa\nObserved Molecular Weight: 50-60 kDa\nGenBank Accession Number: BC002939\nGene Symbol: CLCC1\nGene ID (NCBI): 23155\nRRID: AB_3670441\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein G purification\nUNIPROT ID: Q96S66\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888109703337,"sku":"68853-7-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-68853-7-ig","provider":"Iright","version":"1.0","type":"link"}