{"product_id":"proteintech-80294-2-rr","title":"Proteintech, 80294-2-RR, Phospho-P62\/SQSTM1 (Ser349) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-P62\/SQSTM1 (Ser349) (80294-2-RR) by Proteintech is a Recombinant antibody targeting Phospho-P62\/SQSTM1 (Ser349) in WB, ELISA applications with reactivity to human, mouse samples\n80294-2-RR targets Phospho-P62\/SQSTM1 (Ser349) in WB, ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: sodium arsenite treated HEK-293 cells, MG132 treated NIH\/3T3 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:2000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nSequestosome 1 (SQSTM1\/p62) is a multifunctional adaptor protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis. It functions as a bridge between polyubiquitinated cargo and autophagosomes (PMID:16286508). SQSTM1 is at the cross-roads of several signaling pathways including Keap1-Nrf2 pathway , NFκB pathway , NFE2L2\/NRF2 pathway , mTOR pathway and Wnt pathway. Phosphorylation and\/or de-phosphorylation of p62-Ser349 may participate in the regulation of both selective autophagy and oxidative stress response (PMID: 33397898).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: sequestosome 1\nCalculated Molecular Weight: 48 kDa\nObserved Molecular Weight: 62 kDa\nGenBank Accession Number: BC017222\nGene Symbol: P62\/SQSTM1\nGene ID (NCBI): 8878\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q13501\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888803631273,"sku":"80294-2-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-80294-2-rr","provider":"Iright","version":"1.0","type":"link"}