{"product_id":"proteintech-81219-2-rr","title":"Proteintech, 81219-2-RR, Phospho-SHP2 (Tyr580) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-SHP2 (Tyr580) (81219-2-RR) by Proteintech is a Recombinant antibody targeting Phospho-SHP2 (Tyr580) in WB, ELISA applications with reactivity to human, mouse, rat samples\n81219-2-RR targets Phospho-SHP2 (Tyr580) in WB, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: PDGF treated NIH\/3T3 cells, PDGF treated C6 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nShp2, encoded by the PTPN11 gene, is a protein tyrosine phosphatase that acts as a positive regulator of Ras-Erk pathway. Shp2 contains two tandem Src homology 2 (SH2) domains, a protein tyrosine phosphatase domain and tyrosine phosphorylation sites. It has been suggested that the phosphorylated Tyr542 and Tyr580 recruit Grb2\/Sos complex to activate Ras-Erk signaling. Recently, it was reported that ZAP70, a non-receptor tyrosine kinase, enhances phosphorylation of Shp2 at Tyr580 and activates Erk. (PMID: 23318428)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: protein tyrosine phosphatase, non-receptor type 11\nCalculated Molecular Weight: 597 aa, 68 kDa\nObserved Molecular Weight: 72 kDa\nGenBank Accession Number: BC008692\nGene Symbol: PTPN11\nGene ID (NCBI): 5781\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q06124\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888804417705,"sku":"81219-2-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-81219-2-rr","provider":"Iright","version":"1.0","type":"link"}