{"product_id":"proteintech-81812-4-rr","title":"Proteintech, 81812-4-RR, Phospho-4EBP1 (Thr37) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-4EBP1 (Thr37) (81812-4-RR) by Proteintech is a Recombinant antibody targeting Phospho-4EBP1 (Thr37) in WB, ELISA applications with reactivity to human samples\n81812-4-RR targets Phospho-4EBP1 (Thr37) in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HEK-293T cells, λ phosphatase treated HEK-293T cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\n\u003cb\u003eBackground Information\u003c\/b\u003e\n4EBP1 (4E-BP1) is a translational regulator and functions by sequestering eukaryotic translation initiation factor 4E (eIF4E) from the translation initiation machinery. 4E-BP1 contains at least six phosphorylation sites (Thr37, Thr46, Ser65, Thr70, Ser83, and Ser112), four of which (Thr37, Thr46, Ser65, and Thr70) are known to be regulated by mTOR signaling.  Phosphorylation of Thr37 and Thr46 is thought to prime 4E-BP1 for sequential phosphorylation of Ser65 and Thr70, which results in the dissociation of 4E-BP1 from eIF4E. (PMID: 12747827)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nCited Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: eukaryotic translation initiation factor 4E binding protein 1\nCalculated Molecular Weight: 118 aa, 12 kDa\nObserved Molecular Weight: 15-20 kDa\nGenBank Accession Number: BC004459\nGene Symbol: EIF4EBP1\nGene ID (NCBI): 1978\nRRID: AB_3670507\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q13541\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888534081705,"sku":"81812-4-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-81812-4-rr","provider":"Iright","version":"1.0","type":"link"}