{"product_id":"proteintech-83027-4-rr","title":"Proteintech, 83027-4-RR, SCN4B Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe SCN4B (83027-4-RR) by Proteintech is a Recombinant antibody targeting SCN4B in WB, IHC, FC (Intra), ELISA applications with reactivity to human, mouse, rat samples\n83027-4-RR targets SCN4B in WB, IHC, FC (Intra), ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: U-87 MG cells, HeLa cells,  Ramos cells,  C6 cells,  mouse brain tissue,  human heart tissue\nPositive IHC detected in: rat dorsal root ganglion tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\nPositive FC (Intra) detected in: HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\nImmunohistochemistry (IHC): IHC : 1:500-1:2000\nFlow Cytometry (FC) (INTRA): FC (INTRA) : 0.25 ug per 10^6 cells in a 100 µl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nMammalian sodium channels are heterotrimers, composed of a central, pore-forming alpha subunit and two auxiliary beta subunits (PMID: 11486343). SCN4B (sodium channel subunit beta-4) is one of several sodium channel beta subunits, which modulate channel gating kinetics. SCN4B has an N-terminal signal peptide, a large extracellular domain predicted to form an Ig-like fold, a single transmembrane alpha helix, and a short cytoplasmic C terminus. Defects in SCN4B gene are a cause of long QT syndrome type 10 (LQT10).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: CatNo: Ag34123 Product name: Recombinant human SCN4B protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 31-162 aa of NM_174934.3 Sequence: LEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDNTV Predict reactive species\nFull Name: sodium channel, voltage-gated, type IV, beta\nCalculated Molecular Weight: 25 kDa\nObserved Molecular Weight: 37 kDa\nGenBank Accession Number: NM_174934.3\nGene Symbol: SCN4B\nGene ID (NCBI): 6330\nRRID: AB_3670767\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q8IWT1\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888360935593,"sku":"83027-4-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-83027-4-rr","provider":"Iright","version":"1.0","type":"link"}