{"product_id":"proteintech-83676-5-rr","title":"Proteintech, 83676-5-RR, SLC4A7\/NBCn1 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe SLC4A7\/NBCn1 (83676-5-RR) by Proteintech is a Recombinant antibody targeting SLC4A7\/NBCn1 in WB, ELISA applications with reactivity to human samples\n83676-5-RR targets SLC4A7\/NBCn1 in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: BGC-823 cells, HEK-293 cells,  HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nSLC4A7 also known as NBCn1, NBC3, NBC2, is an electroneutral Na(+)\/HCO(3)(-) cotransporter (PMID: 14736710). SLC4A7 mediates the coupled movement of sodium and bicarbonate ions across the plasma membrane. SLC4A7 plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (PubMed:29779931). SLC4A7 is expressed in testis, spleen, and retina. SLC4A7 may be a major regulator of extracellular pH of retina where light stimulation produces an extracellular alkalization and may contribute as a solute transporter to the prevention of retinal detachment(PMID: 9610397). The molecular weight of SLC4A7\/NBCn1 detected at 150-170 kDa may be due to glycosylation modification.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7\nCalculated Molecular Weight: 136 kDa\nObserved Molecular Weight: 150-170 kDa\nGenBank Accession Number: NM_003615\nGene Symbol: NBCn1\/SLC4A7\nGene ID (NCBI): 9497\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q9Y6M7\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888823259305,"sku":"83676-5-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-83676-5-rr","provider":"Iright","version":"1.0","type":"link"}