{"product_id":"proteintech-84049-1-rr","title":"Proteintech, 84049-1-RR, TOP2B Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe TOP2B (84049-1-RR) by Proteintech is a Recombinant antibody targeting TOP2B in WB, IF\/ICC, ELISA applications with reactivity to human samples\n84049-1-RR targets TOP2B in WB, IF\/ICC, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Jurkat cells, HepG2 cells,  HeLa cells,  K-562 cells,  HEK-293T cells\nPositive IF\/ICC detected in: HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:200-1:800\n\u003cb\u003eBackground Information\u003c\/b\u003e\nTOP2B belongs to the type II topoisomerase family. TOP2B control topological states of DNA by transient breakage and subsequent rejoining of DNA strands. TOP2B makes double-strand breaks. It is indirectly ivolved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: topoisomerase (DNA) II beta 180kDa\nCalculated Molecular Weight: 183 kDa\nObserved Molecular Weight: 180-190 kDa\nGenBank Accession Number: NM_001068\nGene Symbol: TOP2B\nGene ID (NCBI): 7155\nRRID: AB_3671617\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purfication\nUNIPROT ID: Q02880\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888520614057,"sku":"84049-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-84049-1-rr","provider":"Iright","version":"1.0","type":"link"}