{"product_id":"proteintech-84403-1-rr","title":"Proteintech, 84403-1-RR, Phospho-IkB Beta (Thr19\/Ser23) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-IkB Beta (Thr19\/Ser23) (84403-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-IkB Beta (Thr19\/Ser23) in WB, FC (Intra), ELISA applications with reactivity to human samples\n84403-1-RR targets Phospho-IkB Beta (Thr19\/Ser23) in WB, FC (Intra), ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: TNF alpha and Calyculin A treated HT-29 cells\nPositive FC (Intra) detected in: TNF alpha and Calyculin A treated HT-29 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\nFlow Cytometry (FC) (INTRA): FC (INTRA) : 0.25 ug per 10^6 cells in a 100 µl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nIkB Beta is also named as NF-kappa-B inhibitor beta (NFKBIB) and TRIP-9. IKBB is one of the major isoforms of the NFKB inhibitor which preferentially interacts with c-Rel or p65 NF-kB dimers (PMID: 26227166). IKBB was reported to be associated with tumor growth inhibition and metastasis in lung cancer (PMID: 11402320). IKBB also inhibits cancer cell regulation through inactivation of the NFkB pathway (PMID: 18950638). Exposure of cells to a variety of extracellular stimuli leads to the rapid phosphorylation, ubiquitination, and ultimately proteolytic degradation of IkB,  which frees NF-kB to translocate to the nucleus where it regulates gene transcription (PMID: 10837071). The antibody is phosphorylated at Thr19 and Ser23.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nCited Reactivity: rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta\nCalculated Molecular Weight: 356 aa, 38 kDa\nObserved Molecular Weight: 50 kDa\nGenBank Accession Number: BC015528\nGene Symbol: IkB Beta\nGene ID (NCBI): 4793\nRRID: AB_3671932\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purfication\nUNIPROT ID: Q15653\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888684224681,"sku":"84403-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-84403-1-rr","provider":"Iright","version":"1.0","type":"link"}