{"product_id":"proteintech-85044-1-rr","title":"Proteintech, 85044-1-RR, Phospho-PAK1 (Ser144)\/PAK2 (Ser141) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-PAK1 (Ser144)\/PAK2 (Ser141) (85044-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-PAK1 (Ser144)\/PAK2 (Ser141) in WB, ELISA applications with reactivity to human, mouse, rat samples\n85044-1-RR targets Phospho-PAK1 (Ser144)\/PAK2 (Ser141) in WB, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: pervanadate treated C6 cells, LPS treated RAW 264.7 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nThe human PAK family is divided into the group I (PAK1 to PAK3) and group II (PAK4 to PAK6). Group I PAK share some domains that are not present in the group II members. In particular, the autoinhibitory domain (AID) is important for regulation of the kinase activity of the group I family members. Autophosphorylation at PAK1 Ser144, or at the equivalent sites for the other PAK, stabilizes the open conformation and sustains high kinase activity. Mutation of tyrosines 131 or 429 is associated with reduced dimerization and enhanced kinase activity. (PMID: 31748572)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nCited Reactivity: mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: p21 protein (Cdc42\/Rac)-activated kinase 1\nCalculated Molecular Weight: 553 aa, 62 kDa\nObserved Molecular Weight: 61 kDa\nGenBank Accession Number: BC109299\nGene Symbol: PAK1\nGene ID (NCBI): 5058\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purfication\nUNIPROT ID: Q13153\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888534540457,"sku":"85044-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-85044-1-rr","provider":"Iright","version":"1.0","type":"link"}