{"product_id":"proteintech-86038-1-rr","title":"Proteintech, 86038-1-RR, CCR3 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe CCR3 (86038-1-RR) by Proteintech is a Recombinant antibody targeting CCR3 in WB, IF\/ICC, ELISA applications with reactivity to human samples\n86038-1-RR targets CCR3 in WB, IF\/ICC, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: A375 cells, THP-1 cells,  Jurkat cells,  HUVEC cells,  U-87 MG cells\nPositive IF\/ICC detected in: K-562 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:250-1:1000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCCR3 (C-C Motif Chemokine Receptor 3), also known as CD193, is a G protein-coupled receptor (GPCR) primarily involved in immune cell trafficking and inflammation regulation and highly expressed in eosinophils and basophils, with detectable levels in Th2 cells, airway epithelial cells, and subsets of monocyte-derived dendritic cells (PMID: 21077277). Ligand-induced CCR3 internalization is required for eosinophil shape change and actin polymerization but not for calcium mobilization or desensitization (PMID: 12532103).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: chemokine (C-C motif) receptor 3\nCalculated Molecular Weight: 355 aa, 41 kDa\nObserved Molecular Weight: 53 kDa\nGenBank Accession Number: BC110297\nGene Symbol: CCR3\nGene ID (NCBI): 1232\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P51677\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888599716009,"sku":"86038-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-86038-1-rr","provider":"Iright","version":"1.0","type":"link"}