{"product_id":"proteintech-86330-1-rr","title":"Proteintech, 86330-1-RR, Phospho-ATR (Ser428) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-ATR (Ser428) (86330-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-ATR (Ser428) in WB, IF\/ICC, ELISA applications with reactivity to human samples\n86330-1-RR targets Phospho-ATR (Ser428) in WB, IF\/ICC, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HEK-293 cells\nPositive IF\/ICC detected in: HEK-293 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:6000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:200-1:800\n\u003cb\u003eBackground Information\u003c\/b\u003e\nAtaxia-telangiectasia and Rad3 related (ATR) is a serine\/threonine kinase and a member of the phosphatidylinositol 3-kinase-related kinase (PIKK) family, particularly the ataxia telangiectasia mutated (ATM) subfamily. The phosphorylation site of ATR is located at Ser428 and is crucial for proper ATR function. In a series of breast cancer studies, high ATR expression and activation were significantly associated with higher tumor stage, mitotic index, pleomorphism, lymphovascular invasion, and poor survival. (PMID: 33854565)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: ataxia telangiectasia and Rad3 related\nCalculated Molecular Weight: 301 kDa\nObserved Molecular Weight: 300 kDa\nGenBank Accession Number: NM_001184\nGene Symbol: ATR\nGene ID (NCBI): 545\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q13535\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888799666345,"sku":"86330-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-86330-1-rr","provider":"Iright","version":"1.0","type":"link"}