{"product_id":"proteintech-86536-1-rr","title":"Proteintech, 86536-1-RR, SKIV2L2 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe SKIV2L2 (86536-1-RR) by Proteintech is a Recombinant antibody targeting SKIV2L2 in WB, IF\/ICC, ELISA applications with reactivity to human, mouse samples\n86536-1-RR targets SKIV2L2 in WB, IF\/ICC, ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HepG2 cells, IMR-32 cells,  Jurkat cells,  HEK-293 cells,  Neuro-2a cells,  mouse testis tissue\nPositive IF\/ICC detected in: HepG2 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:400-1:1600\n\u003cb\u003eBackground Information\u003c\/b\u003e\nSKIV2L2 (Ski2-like RNA helicase 2, also called Mtr4) is an evolutionarily conserved 3′→5′ RNA helicase belonging to the Ski2-like subfamily of DExH-box helicases.SKIV2L2 is an essential component of the nuclear exosome targeting (NEXT) complex, where it acts as the major ATP-dependent motor that threads RNA substrates into the catalytic core of the RNA exosome for processing and degradation. Through this activity, SKIV2L2 regulates the turnover of aberrant pre-mRNAs, non-coding RNAs, and promoter-associated RNAs, thereby influencing gene expression, ribosomal RNA biogenesis, and maintenance of nuclear RNA homeostasis. It plays a role in cell differentiation and spermatogenesis. Clinically, germline mutations in SKIV2L2 have been associated with tricho-hepato-enteric syndrome, highlighting its importance in intestinal and hepatic development. (PMID: 39863862)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: CatNo: Ag3414 Product name: Recombinant human SKIV2L2 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 3-307 aa of BC028604 Sequence: DAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNGKNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVI Predict reactive species\nFull Name: superkiller viralicidic activity 2-like 2 (S. cerevisiae)\nCalculated Molecular Weight: 1042 aa, 118 kDa\nObserved Molecular Weight: 118 kDa\nGenBank Accession Number: BC028604\nGene Symbol: SKIV2L2\nGene ID (NCBI): 23517\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P42285\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888822276265,"sku":"86536-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-86536-1-rr","provider":"Iright","version":"1.0","type":"link"}