{"product_id":"proteintech-86612-3-rr","title":"Proteintech, 86612-3-RR, C9orf78 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe C9orf78 (86612-3-RR) by Proteintech is a Recombinant antibody targeting C9orf78 in WB, IF\/ICC, ELISA applications with reactivity to human, mouse, rat samples\n86612-3-RR targets C9orf78 in WB, IF\/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HeLa cells, HepG2 cells,  RAW 264.7 cells,  Neuro-2a cells,  NIH\/3T3 cells,  PC-12 cells\nPositive IF\/ICC detected in: HepG2 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:250-1:1000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nThe C9orf72 protein is highly expressed in neurons and microglial cells. Its precise function has not been fully elucidated, but research indicates that it plays an important role in key intracellular pathways such as endosomal vesicle trafficking and autophagy. This protein has garnered significant attention due to its strong association with neurodegenerative diseases.\nAn abnormal expansion of a GGGGCC hexanucleotide repeat sequence in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. This expansion may lead to multiple pathogenic mechanisms, including loss of function (haploinsufficiency) and gain of toxicity (such as the production of toxic dipeptide repeat proteins), ultimately resulting in neuronal death. Consequently, C9orf72 has become a critical research target in the field of neuroscience.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: CatNo: Ag5919 Product name: Recombinant human C9orf78 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-289 aa of BC007664 Sequence: MPVVRKIFRRRRGDSESEEDEQDSEEVRLKLEETREVQNLRKRPNGVSAVALLVGEKVQEETTLVDDPFQMKTGGMVDMKKLKERGKDKISEEEDLHLGTSFSAETNRRDEDADMMKYIETELKKRKGIVEHEEQKVKPKNAEDCLYELPENIRVSSAKKTEEMLSNQMLSGIPEVDLGIDAKIKNIISTEDAKARLLAEQQNKKKDSETSFVPTNMAVNYVQHNRFYHEELNAPIRRNKEEPKARPLRVGDTEKPEPERSPPNRKRPANEKATDDYHYEKFKKMNRRY Predict reactive species\nFull Name: chromosome 9 open reading frame 78\nCalculated Molecular Weight: 34 kDa\nObserved Molecular Weight: 34 kDa\nGenBank Accession Number: BC007664\nGene Symbol: C9orf78\nGene ID (NCBI): 51759\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q9NZ63\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888714666153,"sku":"86612-3-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-86612-3-rr","provider":"Iright","version":"1.0","type":"link"}