{"product_id":"proteintech-87019-1-rr","title":"Proteintech, 87019-1-RR, Phospho-TAU (Ser409) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-TAU (Ser409) (87019-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-TAU (Ser409) in WB, ELISA applications with reactivity to human, mouse samples\n87019-1-RR targets Phospho-TAU (Ser409) in WB, ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: mouse brain tissue\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nPhosphorylation of tau at Ser409 is an early, disease-specific event in Alzheimer's brain. Catalyzed by PKA, this modification weakens tau-microtubule binding and acts as a molecular switch that initiates tau self-aggregation into paired helical filaments. Consequently, p-Ser409-tau is recognized as an early diagnostic epitope and a potential target for interrupting PKA-driven, oxidative-stress-linked tau pathology.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: microtubule-associated protein tau\nCalculated Molecular Weight: 37-46, 79-81 kDa\nObserved Molecular Weight: 45-60 kDa\nGenBank Accession Number: BC000558\nGene Symbol: TAU\nGene ID (NCBI): 4137\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P10636\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888804843689,"sku":"87019-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-87019-1-rr","provider":"Iright","version":"1.0","type":"link"}