{"product_id":"proteintech-87291-1-rr","title":"Proteintech, 87291-1-RR, Phospho-EGFR (Thr693) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-EGFR (Thr693) (87291-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-EGFR (Thr693) in WB, ELISA applications with reactivity to human samples\n87291-1-RR targets Phospho-EGFR (Thr693) in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: EGF treated A431 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nEpidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinase (RTK) family and plays a critical role in a wide variety of cellular functions, including proliferation, differentiation and apoptosis. Phospho-EGFR (Thr693) is a phosphorylated form of the epidermal growth factor receptor (EGFR) at the threonine 693 residue. This phosphorylation event is significant as it is involved in the activation of EGFR signaling pathways. EGFR is known to be a transcriptional co-activator for several cancer-promoting genes, including cyclin D1, nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). (PMID: 34295309) Some scientists call EGFR Thr693 as EGFR Thr669, the site where the signaling peptide is removed.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)\nObserved Molecular Weight: 150-180 kDa\nGenBank Accession Number: NM_005228\nGene Symbol: EGFR\nGene ID (NCBI): 1956\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P00533\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888800813225,"sku":"87291-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-87291-1-rr","provider":"Iright","version":"1.0","type":"link"}