{"product_id":"proteintech-87322-1-rr","title":"Proteintech, 87322-1-RR, Phospho-ALK (Tyr1507) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-ALK (Tyr1507) (87322-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-ALK (Tyr1507) in WB, ELISA applications with reactivity to human samples\n87322-1-RR targets Phospho-ALK (Tyr1507) in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Karpas-299 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nAnaplastic lymphoma kinase was first described in 1994 as the NPM-ALK fusion protein that is expressed in the majority of anaplastic large-cell lymphomas. About 2\/3rds of anaplastic large-cell lymphomas possess a balanced chromosomal translocation in which the entire nucle-ophosmin (NPM) gene on chromosome 5 is fused to the 3' portion of the ALK gene (including the entire intracellular segment with its protein kinase domain) on chromosome 2. This oncogenic ALK protein kinase is a chimeric protein created by a translocation between chromosomes(2;5)(p23;q35) that generates the NPM-ALK fusion protein. NPM-ALK also known as p80, since the chimeric protein weighs 80 kDa. Studies of NPM-ALK have identified pTyr1096 as the binding site for insulin receptor substrate 1 (IRS1);  pTyr1507 is the binding site for Shc and pTyr1604 is the binding site for PLC-Y (native human ALK receptor residue numbers are given; subtract 940 to obtain the NPM-ALK residue). (PMID: 23201355, PMID: 33466277)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: anaplastic lymphoma receptor tyrosine kinase\nObserved Molecular Weight: 80 kDa\nGenBank Accession Number: BC157090\nGene Symbol: ALK\nGene ID (NCBI): 238\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q9UM73\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888799404201,"sku":"87322-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-87322-1-rr","provider":"Iright","version":"1.0","type":"link"}