{"product_id":"proteintech-87327-1-rr","title":"Proteintech, 87327-1-RR, Phospho-BCR (Tyr177) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-BCR (Tyr177) (87327-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-BCR (Tyr177) in WB, ELISA applications with reactivity to human samples\n87327-1-RR targets Phospho-BCR (Tyr177) in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: K-562 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nThe Bcr gene, mapping on chromosome22, was orginally identified by its presence in the chimeric Bcr-Abl oncogene. The aminoterminal BCR-encoded sequences of BCR-ABL contain a tyrosine-phosphorylated site that binds the SH2 domain of the adaptor protein GRB2. It is now evident that the phosphorylation of BCR Tyr177 is essential for BCR-ABL-mediated leukemogenesis, and its mutation largely abolishes GRB2 binding and diminishes BCR-ABL-induced Ras activation. (PMID: 22156549)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: breakpoint cluster region\nCalculated Molecular Weight: 143 kDa\nObserved Molecular Weight: 210 kDa\nGenBank Accession Number: NM_004327\nGene Symbol: BCR\nGene ID (NCBI): 613\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P11274\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888799862953,"sku":"87327-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-87327-1-rr","provider":"Iright","version":"1.0","type":"link"}