{"product_id":"proteintech-87482-1-rr","title":"Proteintech, 87482-1-RR, ITB6 Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe ITB6 (87482-1-RR) by Proteintech is a Recombinant antibody targeting ITB6 in WB, ELISA applications with reactivity to human, mouse, rat samples\n87482-1-RR targets ITB6 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: A431 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nMouse Itgb6 (integrin β6) protein is a member of the integrin family and binds with the αv subunit to form the transmembrane receptor αvβ6. It mediates cell adhesion and migration by recognizing the RGD sequence in the extracellular matrix (such as fibronectin and laminin). The core function of Itgb6 is to act as a key activator of transforming growth factor-β (TGF-β), playing an important role in tissue damage repair, fibrosis, and tumorigenesis. In various mouse tumor models, including pancreatic cancer and skin cancer, high expression of Itgb6 promotes tumor invasion and metastasis, making it an important tumor biomarker and therapeutic target. Its signaling involves pathways such as FAK\/PI3K, regulating cell survival and epithelial-mesenchymal transition (EMT).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: CatNo: Eg10455 Product name: Recombinant mouse ITB6 protein Source: mammalian cells -derived, pHZ-KIsec-C-6*HIS Tag: C-Twin-Strep-Tag Domain: 10011460 of Sequence: \\ Predict reactive species\nFull Name: integrin beta 6\nObserved Molecular Weight: 100 kDa\nGene Symbol: Itgb6\nGene ID (NCBI): 16420\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888772862121,"sku":"87482-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-87482-1-rr","provider":"Iright","version":"1.0","type":"link"}