{"product_id":"proteintech-98639-1-rr","title":"Proteintech, 98639-1-RR, Anti-Guinea Pig CD8a Rabbit Recombinant Antibody","description":"Size: 100ug\nThe CD8a (98639-1-RR) by Proteintech is a Recombinant antibody targeting CD8a in FC applications with reactivity to guinea pig samples\n98639-1-RR targets CD8a in FC applications and shows reactivity with guinea pig samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive FC detected in: guinea pig splenocytes\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nFlow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells , on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-\/CD8+ T cells (PMID: 1968084).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: guinea pig\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: CatNo: Eg7178 Product name: Recombinant guinea pig CD8A protein Source: mammalian cells -derived, V37 Tag: C-rFc Domain: 24-176 aa of NM_001172876.1 Sequence: QGASQFRMSPRELVAQVGTKVTLRCEVLVPNAPAGCSWLFQPRHDAKGPTFLLYHSASGTKLAPGLEQKRFSPSKSSNTYTLTVNSFQKRDEGYYFCSVSGNMMLYFSPFVPVFLPAPRTTTPPPPPTTPTPSVQPTSVRPETCVVSKGAAGA Predict reactive species\nFull Name: CD8 subunit alpha\nCalculated Molecular Weight: 26 kDa\nGenBank Accession Number: NM_001172876.1\nGene Symbol: CD8a\nGene ID (NCBI): 100379570\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q6W8W8\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2 - 8°C. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888693858473,"sku":"98639-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-98639-1-rr","provider":"Iright","version":"1.0","type":"link"}