{"product_id":"proteintech-g66721-1-5c","title":"Proteintech, G66721-1-5C, MultiPro® 5CFLX Anti-Human SYK (4C4A12)","description":"Size: 10ug\nThe SYK (G66721-1-5C) by Proteintech is a Monoclonal antibody targeting SYK in Single Cell (Intra) applications with reactivity to Human samples\nG66721-1-5C targets SYK in Single Cell (Intra) applications and shows reactivity with Human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive Single Cell (Intra) detected in: 10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing product.\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nSINGLE CELL (INTRA): \u0026lt;0.5ug\/test\n\u003cb\u003eBackground Information\u003c\/b\u003e\nSYK(spleen tyrosine kinase) is a key regulator of signal transduction events,apoptosis and orderly cell cycle progression in B-lineage lymphoid cells. Although SYK has not been linked to a human disease, defective expression of the closely related T-cell tyrosine kinase ZAP-70 has been associated with severe combined immunodeficiency(PMID:11494125). This protein has 2 isoforms produced by alternative splicing. SYK also promotes liver fibrosis by activation of hepatic stellate cells and acts as a biomarker for human hepatocellular carcinoma. (PMID: 29537660)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human\nHost \/ Isotype: Mouse \/ IgG2b\nClass: Oligo Conjugate\nType: Monoclonal\nImmunogen: CatNo: Ag17654 Product name: Recombinant human SYK protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 239-427 aa of BC001645 Sequence: QLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL Predict reactive species\nFull Name: MultiPro® 5CFLX Anti-Human SYK (4C4A12)\nCalculated Molecular Weight: 635 aa, 72 kDa\nGenBank Accession Number: BC001645\nGene Symbol: SYK\nGene ID (NCBI): 6850\nENSEMBL Gene ID: ENSG00000165025\nRRID: AB_3673959\nConjugate: 5CFLX\nFull Oligo Sequence: CGGAGATGTGTATAAGAGACAGCGTGATGCGCTGACGCCCATATAAGAAA\nBarcode Sequence: CGTGATGCGCTGACG\nForm: Liquid\nUNIPROT ID: P43405\nStorage Buffer: PBS with 1mM EDTA and 0.09% sodium azide , pH 7.3.\nStorage Conditions: 2-8°C Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888299921577,"sku":"G66721-1-5C","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-g66721-1-5c","provider":"Iright","version":"1.0","type":"link"}