{"product_id":"proteintech-khc1335","title":"Proteintech, KHC1335, IHCeasy® ITGB3\/CD61 Ready-To-Use IHC Kit","description":"Size: 50t (no control slide) \/ 50t (with control slide)\n\u003cb\u003eBackground Information\u003c\/b\u003e\nIntegrin beta-3, also named as CD61 and GPIIIa, is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor.  Integrin beta-3 recognize the sequence R-G-D in a wide array of ligands and the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain.  Following activation integrin beta-3 brings about platelet\/platelet interaction through binding of soluble fibrinogen which leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.  In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.\n\u003cb\u003eSpecification\u003c\/b\u003e\nProduct name: IHCeasy ITGB3\/CD61 Ready-To-Use IHC Kit\nSample type: FFPE tissue\nAssay type: Immunohistochemistry\nPrimary antibody type: Mouse Monoclonal\nSecondary antibody type: Polymer-HRP-Goat anti-Mouse\nReactivity: Human, Mouse, Rat","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888882831529,"sku":"KHC1335","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/proteintech-khc1335","provider":"Iright","version":"1.0","type":"link"}