{"product_id":"revvity-2hfab647ph1","title":"Revvity, 2HFAB647PH1, PhenoVue Fluor 647 pH-sensitive Fab Anti-human IgG - 2 x 96 wells","description":"\u003cp\u003eOverview\u003cbr\u003e\nThe study of antibody internalization is important in the research and development of antibody-drug conjugates (ADCs), a rapidly expanding class of biopharmaceuticals that link a monoclonal antibody to a cytotoxic payload via a cleavable linker. Upon internalization and lysosomal processing, the payload is released, triggering cell death through mechanisms such as DNA damage or microtubule disruption. Assessment of antibody internalization is therefore critical for the design, optimization, and evaluation of ADCs and related biologics.\u003cbr\u003e\nThe PhenoVue Fluor 647 pH-sensitive Fab anti-human IgG is available as an individual reagent and is also a key component of the PhenoVue human IgG antibody internalization kit (Fluor 647, pH-sensitive). In both formats, the probe is compatible with standard cell culture conditions and exerts minimal impact on cell viability and proliferation, providing reproducible results even during extended time-lapse imaging. Color-Deep Red\u003cbr\u003e\nForm-Liquid\u003cbr\u003e\nMaximum Emission Wavelength (Em-670 nm\u003cbr\u003e\nMaximum Excitation Wavelength (Ex-650 nm\u003cbr\u003e\nApplication-High Content Imaging Microscopy\u003cbr\u003e\nAssay Points-2 x 96-well or 1 x 384-well microplates\u003cbr\u003e\nBrand-PhenoVue™\u003cbr\u003e\nDetection Modality-Fluorescence\u003cbr\u003e\nFilter-Cy5\u003cbr\u003e\nHost Species-Goat\u003cbr\u003e\nProduct Group-Antibody\u003cbr\u003e\nQuantity-1\u003cbr\u003e\nSample Type-Live cells only\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nStorage Conditions--16° C or below, protected from light\u003cbr\u003e\nTarget Species-Human\u003cbr\u003e\nType-Individual reagent\u003cbr\u003e\nUnit Size-100 µL\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775376642217,"sku":"2HFAB647PH1","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-2hfab647ph1","provider":"Iright","version":"1.0","type":"link"}