{"product_id":"revvity-62hil15peg","title":"Revvity, 62HIL15PEG, HTRF Human IL-15 Detection Kit, 500 Assay Points","description":"\u003cp\u003eOverview\u003cbr\u003e\nHuman Interleukin 15 (IL-15) is a cytokine that is initially produced as a precursor that matures into a 114-amino acid glycoprotein. IL-15 is generated by multiple tissues, including the placenta, skeletal muscle, kidney, lung, heart, and monocytes\/macrophages. IL-15 acts mainly on T and B cells and is a key cytokine in the development, proliferation, and survival of natural killer cells.\u003cbr\u003e\nIL-15 binds with high affinity to the IL-15 receptor α and forms a complex with the α and γ chains of the IL-2 receptor for signal transduction. It can regulate inflammatory responses and activate NK cells during immune responses. IL-15 signaling has become a focus of interest for therapeutic interventions, especially in autoimmune diseases such as inflammatory bowel disease, systemic lupus erythematosus, inflammatory synovitis, psoriasis, diabetes mellitus, asthma bronchiale, rheumatoid arthritis, and T-cell leukemia.\u003cbr\u003e\nHow it works\u003cbr\u003e\nAssay principle\u003cbr\u003e\nCell supernatant, sample, or standard is dispensed directly into the assay plate for the detection by HTRF® reagents (384-well low-volume white plate or Revvity low-volume 96-well plate in 20 µl). The antibodies labeled with the HTRF donor and acceptor are pre-mixed and added in a single dispensing step, to further streamline the assay procedure. The assay can be run in up to a 1536-well format by simply resizing each addition volume proportionally. Application-Protein Quantification\u003cbr\u003e\nBrand-HTRF\u003cbr\u003e\nDetection Modality-HTRF\u003cbr\u003e\nProduct Group-Kit\u003cbr\u003e\nSample Volume-16 µL\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nTarget Class-Cytokines\u003cbr\u003e\nTarget Species-Human\u003cbr\u003e\nTechnology-TR-FRET\u003cbr\u003e\nUnit Size-500 assay points\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775278502057,"sku":"62HIL15PEG","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-62hil15peg","provider":"Iright","version":"1.0","type":"link"}