{"product_id":"revvity-64npmttda","title":"Revvity, 64NPMTTDA, HTRF Human and Mouse Total NPM1 Detection Kit, Control Lysate","description":"\u003cp\u003eOverview\u003cbr\u003e\nNPM1 (Nucleophosmin 1) is a molecular chaperone involved in cell cycle regulation, ribosome biogenesis, cell proliferation, DNA damage repair, and apoptosis. Its phosphorylation on Thr199 by the CDK2\/Cyclin E complex regulates mitosis, centrosome duplication, pre-mRNA processing, and G2\/M cell cycle arrest through its interaction with p53\/MDM2.\u003cbr\u003e\nNPM1 functions both as an oncogene and a tumor suppressor. It is frequently overexpressed, altered, and rearranged, or sporadically deleted, in human cancers. NPM1 is also the most frequently mutated gene (NPM1c) in acute myeloid leukemia (AML). Application-Cell Signaling\u003cbr\u003e\nAutomation Compatible-Yes\u003cbr\u003e\nBrand-HTRF\u003cbr\u003e\nDetection Modality-HTRF\u003cbr\u003e\nMolecular Modification-Total\u003cbr\u003e\nProduct Group-Control Lysate\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nTarget-NPM1\u003cbr\u003e\nTarget Class-Phosphoproteins\u003cbr\u003e\nTarget Species-Human Mouse\u003cbr\u003e\nTechnology-TR-FRET\u003cbr\u003e\nTherapeutic Area-Oncology\u003cbr\u003e\nUnit Size-1 vial\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775266771113,"sku":"64NPMTTDA","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-64npmttda","provider":"Iright","version":"1.0","type":"link"}