{"product_id":"revvity-al387hv","title":"Revvity, AL387HV, AlphaLISA Human TDP-43 Detection Kit, 100 Assay Points","description":"\u003cp\u003eOverview\u003cbr\u003e\nFormats:\u003c\/p\u003e\n\n\u003cp\u003eOur 100 assay point kit allows you to run 100 wells in 96-well format, using a 100 µL reaction volume (10 µL of sample).\u003cbr\u003e\nOur 500 assay point kit allows you to run 500 wells in 96-well or 384-well format, using a 50 µL reaction volume (5 µL of sample).\u003cbr\u003e\nOur 5,000 assay point kit allows you to run 5,000 wells in 96-well or 384-well format, using a 50 µL reaction volume (5 µL of sample).\u003c\/p\u003e\n\n\u003cp\u003eFeatures:\u003c\/p\u003e\n\n\u003cp\u003eNo-wash steps, no separation steps\u003cbr\u003e\nELISA alternative technology\u003cbr\u003e\nSensitive detection\u003cbr\u003e\nBroad sample compatibility\u003cbr\u003e\nSmall sample volume\u003cbr\u003e\nResults in less than 3 hours\u003cbr\u003e\nHalf the time of an ELISA assay\u003c\/p\u003e\n\n\u003cp\u003eTAR DNA-binding protein 43 (TDP-43, transactive response DNA binding protein 43 kDa) is a transcriptional repressor protein. Excess amounts of protein inside the nucleus of nerve cells have been reported in two fatal neurodegenerative diseases - amyotrophic lateral sclerosis (ALS), and fronto-temporal dementia (FTD). As such, it is becoming an important biomarker of neurological disease and target for intervention. This AlphaLISA kit has been designed to detect and quantify Human TDP-43 in human serum, CSF, cell culture supernatants, and cell lysates.p\u0026gt;\u003cbr\u003e\nAlphaLISA technology allows the detection of molecules of interest in a no-wash, highly sensitive, quantitative assay. In an AlphaLISA assay, a biotinylated anti-analyte antibody binds to the Streptavidin-coated Donor beads while another anti-analyte antibody is conjugated to AlphaLISA Acceptor beads. In the presence of the analyte, the beads come into close proximity. The excitation of the Donor beads causes the release of singlet oxygen molecules that triggers a cascade of energy transfer in the Acceptor beads, resulting in a sharp peak of light emission at 615 nm. \u003cbr\u003e\nApplication-Protein Analysis \u0026amp; Detection\u003cbr\u003e\nAssay Points-100\u003cbr\u003e\nAutomation Compatible-Yes\u003cbr\u003e\nBrand-AlphaLISA\u003cbr\u003e\nDetection Modality-Alpha\u003cbr\u003e\nFormat-Microplates\u003cbr\u003e\nHost Species-Human\u003cbr\u003e\nShipping Conditions-Shipped in Blue Ice\u003cbr\u003e\nTarget-TDP-43\u003cbr\u003e\nTarget Class-Protein\u003cbr\u003e\nTherapeutic Area-Central Nervous System\u003cbr\u003e\nUnit Size-100 Assay Points\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46774545186985,"sku":"AL387HV","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-al387hv","provider":"Iright","version":"1.0","type":"link"}