{"product_id":"revvity-alsu-adap12-a10k","title":"Revvity, ALSU-ADAP12-A10K, AlphaLISA Human DAP12 Aggregation Kit, 10,000 Assay Points","description":"\u003cp\u003eOverview\u003cbr\u003e\nDAP12, also known as TYRO protein tyrosine kinase-binding protein, functions as a signaling adapter for a number of innate immune system cell surface receptors. By activating SYK or Zap-70 and other downstream targets, crosslinking receptors linked to DAP12 causes tyrosine residues in their cytoplasmic ITAM to be phosphorylated by SRC family kinases, which initiates downstream signaling. By monitoring the neuronal surroundings and preserving a healthy brain homeostasis in microglia cells, the TREM2-DAP12 receptor complex seems to play an ongoing role.\u003cbr\u003e\nThe AlphaLISA SureFire Human Aggregate DAP12 Detection Kit is a sandwich immunoassay for the quantitative detection of aggregate DAP12 in cellular lysates, using Alpha Technology.\u003cbr\u003e\nFormats:\u003c\/p\u003e\n\n\u003cp\u003eThe HV (high volume) kit contains reagents to run 100 wells in 96-well format, using a 60 μL reaction volume.\u003cbr\u003e\nThe 500-point kit contains enough reagents to run 500 wells in 384-well format, using a 20 μL reaction volume.\u003cbr\u003e\nThe 10,000-point kit contains enough reagents to run 10,000 wells in 384-well format, using a 20 μL reaction volume.\u003cbr\u003e\nThe 50,000-point kit contains enough reagents to run 50,000 wells in 384-well format, using a 20 μL reaction volume.\u003c\/p\u003e\n\n\u003cp\u003eAlphaLISA SureFire Ultra kits are compatible with:\u003c\/p\u003e\n\n\u003cp\u003eCell and tissue lysates\u003cbr\u003e\nAntibody modulators\u003cbr\u003e\nBiotherapeutic antibodies\u003c\/p\u003e\n\n\u003cp\u003eAlpha SureFire kits can be used for:\u003c\/p\u003e\n\n\u003cp\u003eCellular kinase assays\u003cbr\u003e\nReceptor activation studies\u003cbr\u003e\nScreening \u003cbr\u003e\nApplication-Cell Signaling\u003cbr\u003e\nAutomation Compatible-Yes\u003cbr\u003e\nBrand-AlphaLISA SureFire Ultra\u003cbr\u003e\nDetection Modality-Alpha\u003cbr\u003e\nLysis Buffer Compatibility-Lysis Buffer\u003cbr\u003e\nProduct Group-Kit\u003cbr\u003e\nSample Volume-10 µL\u003cbr\u003e\nShipping Conditions-Shipped in Blue Ice\u003cbr\u003e\nTarget-DAP12\u003cbr\u003e\nTarget Class-Phosphoproteins\u003cbr\u003e\nTarget Species-Human\u003cbr\u003e\nTechnology-Alpha\u003cbr\u003e\nTherapeutic Area-Neuroscience\u003cbr\u003e\nUnit Size-10,000 assay points\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46774610788521,"sku":"ALSU-ADAP12-A10K","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-alsu-adap12-a10k","provider":"Iright","version":"1.0","type":"link"}