{"product_id":"revvity-net1033001mc","title":"Revvity, NET1033001MC, WIN 35428, [N-Methyl- H]-, 1mCi (37MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\n1 mCi quantity of WIN 35428, [N-Methyl-3H]-, is available for your research. WIN 35428 is a dopamine reuptake inhibitor, and is a stimulant drug. These transporters are potential drug targets for attention deficit hyperactivity disorder (ADHD), bipolar disorder, clinical depression, and alcohol addiction.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET1033:\u003c\/p\u003e\n\n\u003cp\u003eHong, W.C., Yano, H., Hiranita, T., Chin, F.T., McCurdy, C.R., Su, T., Amara, S.G., Katz, J.L., The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats. Journal Biological Chemistry, 2017, 292 (27): 11250-11261.\u003cbr\u003e\nHong, W.C., and Amara, S.G., Membrane Cholesterol Modulates the Outward Facing Conformation of the Dopamine Transporter and Alters Cocaine Binding. Journal of Biological Chemistry, 2010, 285 (42): 32616-32626. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-277.3\u003cbr\u003e\nSpecific Activity-60 - 87 Ci\/mmol (2220 - 3219 GBq\/mmol)\u003cbr\u003e\nCAS Number-50370-56-4\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C16H20FNO2\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Dopamine\u003cbr\u003e\nShipping Information-Shipped in Dry Ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic\u003cbr\u003e\nUnit Size-1 mCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775411048617,"sku":"NET1033001MC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net1033001mc","provider":"Iright","version":"1.0","type":"link"}