{"product_id":"revvity-net1041250uc","title":"Revvity, NET1041250UC, AF-DX 384, [2,3-Dipropylamino- H]-, 250µCi (9.25MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\nAFDX-384 is a drug targeting M2 and M4 muscarinic receptors, and is used for mapping receptor distribution in the brain. Muscarinic acetylcholine receptors (mAChRs) are GPCRs that play a role in the parasympathetic nervous system. Muscarinic acetylcholine receptors are potential targets for dementia and schizophrenia.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET1041:\u003c\/p\u003e\n\n\u003cp\u003eA.V. Terry, D.A. Gearhart, S.P. Mahadik, S. Warsi, J.L. Waller, Chronic treatment with first or second generation antipsychotics in rodents: Effects on high affinity nicotinic and muscarinic acetylcholine receptors in the brain, In Neuroscience, Volume 140, Issue 4, 2006, Pages 1277-1287. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-478.6\u003cbr\u003e\nSpecific Activity-100 - 160 Ci\/mmol (3700 - 5920 GBq\/mmol)\u003cbr\u003e\nCAS Number-118290-26-9\u003c\/p\u003e\n\n\u003cp\u003eApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol with 0.5N HCl\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C27H38N6O\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Acetylcholine (Muscarinic)\u003cbr\u003e\nShipping Information-Shipped in Dry Ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-Cardiovascular CNS \u0026amp; Neurologic Gastrointestinal\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46774515171497,"sku":"NET1041250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net1041250uc","provider":"Iright","version":"1.0","type":"link"}